Facing a Sam deck will generally net you a lot of draws off of him, but anything else is generally 1-2.
My D4 was against a prophets/priests/angels deck with Moses in it. Seraph+Isaiah, Joseph, Samuel, Ezekiel, Angels + Judges, etc. all individually give a CBN D2.
Well sure, there are exceptions; in general though, you won't be able to net more than 2 cards per turn off of him. All of the examples you gave would be the 2 cards, but right now the four most popular offenses are Genesis (two draws if Joseph is out), Sam (over 9000 draws), Disciples (two draws), and TGT (three draws, especially if Gardensciples).
I'm saying base ur Deck on the Auto-win Characters. There are Curses that help lots of cards. Yesturday I heard of a strategy that could in-essence give u an Auto-win if it's pulled off correctly. I really don't see how this strategy can destroy Isaiah Decks.
Characters like Zimri or Ortho aren't auto-win characters, since they can be interrupted quite easily. This makes them unreliable and thus not generally considered good choices for any defense, let alone standalone. Realistically, the only real "auto-block" is Uzzah, and that's assuming that he is not negated.
