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Ezekiel 34_6 (Pi)
Type: Lost Soul • Brigade: None • Ability: None • Class: None • Special Ability: If this card is in your territory during your preparation phase, you may exchange it with a Lost Soul in an opponent’s territory (except another copy of this card). • Identifiers: None • Verse: Ezekiel 34:6 • Availability: Priests booster packs (Uncommon)
See also:
•      Exchange

Benedictus (Di)
Type: Hero Enh. • Brigade: Teal/White • Ability: 2 / 4 • Class: Territory • Special Ability: Negate all special abilities on Sites and Lost Souls this turn. Your Heroes have access to all Sites this turn. • Identifiers: NT, Based on Prophecy, Involves Music • Verse: Luke 1:68-69 • Availability: Disciples booster packs ()

You exchange wanderer for one of your opponent's lost souls. You then play benedictus, what happens to the exchange. Does it stick, or does benedictus negate that exchange? 

3-Liner is correct - If you play benedictus during the same phase you exchange then the exchange is negated.

Well, actually the main problem was you, Chris and I were fairly certain that we could get past Justin at least the first time, the trick was if you had an awesome brown dude like Uzzah just chillaxing in hand.  and then of course the possiblity of Justin drawing a hero. But yeah, if it had been a two player game I probably would have decided a lot faster - but Chris changed his mind a few times.

I believe they activate when they hit the table, but they have different conditions or triggers that must be met for them to be carried out.

sounds good to me