My, look at all the questions I've had lately. Heavens to Celestia.
At any rate, I'm pretty sure I know the answer to this one, but regardless.
Let's say we have Aaron, John, and James son of Zebedee from the starter decks. It's our Preparation Phase, and we plays Meeting in the Wilderness. (Green/Set 2 Heroes aside, this that the other thing).
Aaron activates the Enhancement on Aaron, but can the targets be John and James?