You can play Burial on the card and it discards it like any other Lost Soul. A common play is to let an opponent "rescue" half and then play Burial, or give them the Shuffler Lost Soul, or shuffle it with Death of Unrighteous so that the 2/3-liner resets and they lose the half they had.
If a player has rescued both halves of it and the card is in their Land of Redemption, you can play Falling Away and the card will return to your Land of Bondage with one half still being considered "rescued" for that player (though their score decreases by 2 since the half they still have is stuck in territory).