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6. Basically if it has the same name and same picture, it's a duplicate. Otherwise they are not duplicates.
1. Immune and protect are now the same. Basically, they cannot discard you by battle and you are unaffected by all their card effects unless the protection is negated (or a card says regardless of Protection.) You may not necessarily win a Lost Soul or stop your Opponent from obtaining a Lost Soul, but regardless you'll keep the character.2. There is no limit or minimum of brigades you have to use. You typically will use 2 at least, (1 Good and 1 Evil) but beyond that you can use any number of brigades.3. Okay, so Interrupt stops what's going on, applies the effect of the card and then lets the original effect complete if the card that was interrupted and a character that can use it is still in battle. You can use a negate against an interrupt all the same though. Just as he can interrupt your negate.4. I would have to read the card but if it just says "When Discarded" then yes, it would. But that would only apply to what the card states. Not to all characters.5. Yes. You can have as many Sites in your deck up to the number of Lost Souls in your Deck. Same thing with Dominants.6. Basically if it has the same name and same picture, it's a duplicate. Otherwise they are not duplicates.
Try and negate their abilities with cards like Foul Spirit, Sapphira, King of Tyrus, etc. You could also try underdecking them with Scattered, which if played against at least twoHeroes in battle Scattered's ability is Cannot he Negated (which also means it can't be prevented and/or interrupted either). Try any other ability other than discard or defeat by the numbers to get rid of them from battle such as underdeck, set-aside, Banish (remove from the game), shuffle, etc.