Partially. If you used an ITB card, it would not Negate The Destroyer's Discard, but it would Interrupt his impending Removal. So if you blocked The Destroyer, played Dream, and then played Colosseum Lions, The Destroyer would go to Discard/Chamber. Alternately, if The Destroyer was gathered to a Green Hero, he could use the Discard portion of his SA, then play Visions of Iddo the Seer to Interrupt his own pending Removal and return to hand.