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How to UseAn interrupt or negate card must be played during the Battle Phase. Interrupt cards can only be played if the player has initiative. Initiative may be passed back to you if the character(s) being discarded, captured, or placed back in your hand put you in a situation where you are not winning. An interrupt cannot undo a prevent command if the prevent is preventing the interrupt.
Since Deafening Spirit is an Evil Character, you could not interrupt THAT card.Since Following Demons is still causing you to lose by removal, Reach can be played to interrupt THAT ability and do your thing.