I haven't really thought about doing this type of a defense before, but I feel a sitelock + setaside defense could work.
Rough version I just made:
Cards in deck: 35
Lost Souls: 7
Lost Soul (Color Guard)
Lost Soul (deck discard)
Lost Soul (Female Only)
Lost Soul (N.T. only)
Lost Soul (shame)
Lost Soul (Site Discard)
Lost Soul (Wanderer)
Fortresses: 2
High Places
Kingdoms of the World
White Sites: 1
Mildewed House
Red Sites: 3
Babylon
Lion's Den
Lion's Den
Green Sites: 1
Babylonian Banquet Hall
Blue Sites: 1
Hormah
Purple Sites: 1
Pergamum
White Covenant Cards: 2
Plagued with Diseases (Brown)
Wastelands (Orange)
Crimson Evil Characters: 1
Red Dragon
Brown Evil Characters: 5
Haman
King Ahaz
King Jeroboam I
King Nadab
Persian Presidents
Multi-Color Evil Enhancements: 2
Demonic Blockade (orange/brown)
Two Possessed by Demons (Orange)
Crimson Evil Enhancements: 1
Nebuchadnezzar's Pride
Brown Evil Enhancements: 5
Image of Jealousy
Siege
Taking Naboth's Vineyard
Threatened Lives
Weakness
It seems a sitelock version of this would ONLY work in large defenses, which is what I'm used to.